Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/367"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"route of administration: oral
study duration: at least 27 days
population: 11 subjects
tested for known CYP450 polymorphisms?
NO
ages: none given
description:
SUBJECTS: 11 subjects received fluoxetine treatment (n = 4 placebo first, n = 7 alprazolam first).
METHODS: The study had a within-subject, double-blind, placebo-controlled, parallel design. Subjects attended 4 study sessions; the first 2 study sessions occurred in the absence of SSRI medications, while the final 2 sessions occurred after a minimum of 21 days of administration of SSRI medication (citalopram 20 mg or fluoxetine 20 mg). Study sessions took place at least 3 days apart. At each study session, subjects were randomly assigned to a single oral dose of alprazolam (1 mg) or placebo at 9:00 am in the morning (ie, 1 of each for the 2 sessions before SSRI administration and 1 of each for the final 2 sessions after SSRI administration). During the post-SSRI study sessions, daily SSRI dosing was continued, while blood samples were collected up to 48.0 hours (ie, SSRIs were administered at 24.0 and 48.0 hours after single-dose alprazolam administration). Trough citalopram, fluoxetine, and metabolite serum concentrations were determined on 5 occasions: on days 1 and 7 of SSRI administration, prior to alprazolam/placebo administration at study sessions 3 and 4, and 7 days after discontinuation of study medications. During the study sessions, a small standardized breakfast (bagel and apple juice) was provided 1 hour postalprazolam administration, and a sandwich and apple juice was provided 4 hours postalprazolam administration. From 8 hours postalprazolam administration, food intake was not regulated. Subjects were instructed not to consume grapefruit juice during the study due to the potential for inhibition of the CYP3A4 enzyme.
RESULTS: Coadministration with fluoxetine significantly increased alprazolam AUC for all time intervals: 0-3 hours (P < 0.05), 0-8 hours (P < 0.005), 0-48 hours (P < 0.001), and 0-inf ( P < 0.001) (Table 2 and Fig. 1). The AUC 0-inf increased by 31.8% postfluoxetine."
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| dc:creator | |
| dc:date |
"09/22/2010 15:33:48"
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluoxetine_increases_auc_alprazolam, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1828 }