Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/403"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1332"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"75"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:claim_assumed_valid_for_evidence_application_evidence_1332	?:tolbutamide_in_vitro_probe_substrate_of_enzyme_cyp2c9
?:content	"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) probe reaction: tolbutamide --> hydroxytolbutamide Quote: CYP2C9. R-CT, S-CT, R-DCT, and S-DCT were weak inhibitors of CYP2C9, represented by tolbutamide hydroxylation, with less than 50% inhibition produced even at 250micM. R-DDCT and S-DDCT produced a moderate degree of inhibition, with IC50 values of 30.7 (+/-6.3)micM and 25.7 (+/-8.0)micM, respectively. Sulfaphenazole was a strong inhibitor (IC50 1.3micM), and the SSRI fluvoxamine also was a moderately strong inhibitor (IC50 9.4micM)."
dc:creator	"boycer"
dc:date	"06/11/2009 15:15:34"
rdfs:seeAlso	?:11454728

The resource appears as object in one triple:

{ escitalopram_inhibits_cyp2c9, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1332 }

Context graph