Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/411"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1387"
|
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"Route of administration: oral
study duration: 13 days
population: 18 participants; 5 male, 5 female
ages:18-45
dose: 20mg of atorvastatin on day one, three days no drug, days 6-10 participants were given 200mg itraconazole 1xday for 5 days, on day 10 a portion of the participants were given a single dose of 20 mg atorvastatin. PK parameters were measured followed for another three days
(mean AUC_i)/(mean AUC) = 246.7/98.7 (AUC is 0-infinity)
description:
n this single-site, randomized, three-way crossover, open-labeled study, healthy subjects (n = 18) received single doses of cerivastatin 0.8 mg, atorvastatin 20 mg, or pravastatin 40 mg without and with itraconazole 200 mg. Pharmacokinetic parameters [AUC(0-infinity), AUC(0-tn), peak concentration (Cmax), time to reach Cmax (tmax), and half-life (t1/2)] were determined for parent statins and major metabolites. RESULTS: Concomitant cerivastatin/itraconazole treatment produced small elevations in the cerivastatin AUC(0-infinity), Cmax, and t1/2 (27%, 25%, and 19%, respectively; P < .05 versus cerivastatin alone). Itraconazole coadministration produced similar changes in pravastatin pharmacokinetics [AUC elevated 51% (P < .05 versus pravastatin alone), 24% (Cmax), and 23% (t1/2), respectively]. However, itraconazole dramatically increased atorvastatin AUC (150%), Cmax (38%), and t1/2 (30%) (P < .05)."
|
| dc:creator | |
| dc:date |
"09/24/2007 10:14:08"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ itraconazole_increases_auc_atorvastatin, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1387 }