Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/431"
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rdf:type | |
rdf:type | |
rdfs:label | |
?:Evidence_type | |
?:Evidence_assump_list_id |
"78"
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?:Evidence_enzyme_system | |
?:claim_assumed_valid_for_evidence_application_evidence_1855 | |
dc:creator | |
dc:date |
"08/09/2007 07:14:30"
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?:content |
"Route of administration: oral
polymorphic enzyme: yes
study duration: single 120mg oral dose of diltiazem with 24 hours of plasma level monitoring
population: 15 individuals; 5 for each genetically based phenotype. Study does not state gender of participants
ages: 20-30
description:
The aim of this study was to compare the pharmacokinetics of diltiazem and its major metabolites in healthy human volunteers representing different CYP2D6 genotypes. METHODS: Norwegians of Caucasian origin were screened for their CYP2D6 genotype on the LightCycler (Roche Diagnostics, Mannheim, Germany) by melting-curve analysis of allele-specific fluorescence resonance energy transfer probes hybridized to polymerase chain reaction-amplified deoxyribonucleic acid. The first 5 individuals identified with genotypes corresponding to a homozygous extensive, heterozygous extensive, or homozygous poor CYP2D6-metabolizing phenotype, respectively, were voluntarily enrolled in the pharmacokinetic study. The participants received diltiazem, 120 mg, as a single oral dose, and plasma samples were collected up to 24 hours after administration. Plasma samples were purified by solid phase extraction. Diltiazem and 7 phase I metabolites were analyzed by liquid chromatography-mass spectrometry. RESULTS: The pharmacokinetics of diltiazem was not significantly different between the subgroups. ..."
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rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ diltiazem_primary_metabolic_clearance_enzyme_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1855 }