Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/462"

PredicateValue (sorted: default)
rdfs:label
"evidence_1796"
rdf:type
?:Evidence
?:Item
?:Evidence_assump_list_id
"87"
?:Evidence_enzyme_system
""
?:Evidence_type
?:EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem
?:claim_assumed_valid_for_evidence_application_evidence_1796
?:sulphaphenazole_in_vitro_selective_inhibitor_of_enzyme_cyp2c9
?:content
"Enzyme system: human liver microsomes NADPH added: yes inhibitor used: sulphaphenazole reaction: haloperidol --> 4-(4-chlorophenyl)-4-hydroxypiperidine Quote: Ketoconazole was a potent inhibitor of CPHP (4-(4-chlorophenyl)-4-hydroxypiperidine) formation with IC50 values of 0,10, 0,23 and 0,14 micM in microsomes HL-1, HL-6 and HL-9 respectively, wheras sulphaphenazole, furafylline and quinidine showed little inhibition (IC50 > 100micM)"
dc:creator
"boycer"
dc:date
"06/11/2009"
rdfs:seeAlso
?:9431831

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ cyp2c9_controls_formation_of_4-(4-chlorophenyl)-4-hydroxypiperidine, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1796 }

Context graph