Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/498"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1925"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"94"
?:Evidence_enzyme_system	"Human_Liver_Microsomes"
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:Evidence_value	"0.001"
?:claim_assumed_valid_for_evidence_application_evidence_1925	?:testosterone_in_vitro_probe_substrate_of_enzyme_cyp3a4
?:content	"Enzyme system: human liver microsomes NADPH added: yes substrate used: testosterone reaction: testosterone-->6beta-OH-testosterone Quote: Verapamil and diltiazem inhibited testosterone 6beta-hydroxylation in a time- and concentration-dependent manner, key features of mechanism-based inactivation. Values for the inactivation parameters kinact and KI were 0.15 +/- 0.04 min-1 (mean +/- s.d.) and 2.9 +/- 0.6 microM, respectively, for verapamil and 0.07 +/- 0.01 min-1 and 3.3 +/- 1.5 microM, respectively, for diltiazem."
dc:creator	"boycer"
dc:date	"07/02/2007 17:27:00"
rdfs:seeAlso	?:11422004

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ diltiazem_inhibition_constant_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1925 }

Context graph