Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/498"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdf:type | |
| rdfs:label | |
| ?:Evidence_type | |
| ?:Evidence_assump_list_id |
"94"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_value | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1925 | |
| dc:creator | |
| dc:date |
"07/02/2007 17:27:00"
|
| ?:content |
"Enzyme system: human liver microsomes
NADPH added: yes
substrate used: testosterone
reaction: testosterone-->6beta-OH-testosterone
Quote:
Verapamil and diltiazem inhibited testosterone 6beta-hydroxylation in a time- and concentration-dependent manner, key features of mechanism-based inactivation. Values for the inactivation parameters kinact and KI were 0.15 +/- 0.04 min-1 (mean +/- s.d.) and 2.9 +/- 0.6 microM, respectively, for verapamil and 0.07 +/- 0.01 min-1 and 3.3 +/- 1.5 microM, respectively, for diltiazem."
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ diltiazem_inhibition_constant_cyp3a4, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1925 }