Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/5"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1017"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"2"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome
?:claim_assumed_valid_for_evidence_application_evidence_1017	?:phenacetin_in_vitro_probe_substrate_of_enzyme_cyp1a2
?:content	"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) probe reaction: phenacetin O-deethylation Quote: In all systems the positive control inhibitors produced the expected degree of inhibition of their respective index reactions (Table 1). CYP1A2. R- and S-CT and metabolites all were negligible inhibitors of phenacetin O-deethylation, the index reaction for CYP1A2. None of these compounds produced 50% inhibition. The mean IC50 for alpha-naphthoflavone was 0.2micM, and the mean IC50 for fluvoxamine was 0.3micM."
dc:creator	"boycer"
dc:date	"06/12/2009 11:40:41"
rdfs:seeAlso	?:11454728

The resource appears as object in one triple:

{ R-didemethylcitalopram_inhibits_cyp1a2, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1017 }

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