Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/509"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"NOTE: The object dose is the dose of aminophylline and is equivalent to 0.2765 g of anhydrous theophylline. The AUC_i/AUC is from table 2.
route of administration: iv (object), oral (precip)
study duration: 9 days
population: 7 healthy subjects (all male); 5 smokers, 2 nonsmokers
tested for known CYP450 polymorphisms?
NO
ages: 25-44
description:
SUBJECTS: 7 subjects in group 2 (5 smokers, 2 nonsmokers) age ranged from 25-44 (mean 34 +/- 8.3yrs.) and weight from 69.9-81.2 kg (mean 74.0 +/- 4.2 kg). Eighty-four percent of subjects were smokers. Sixty-three percent were Caucasian and 37% were African-American.
METHODS: A two-way, randomized, crossover study was performed to assess the pharmacokinetics of theophylline administered with placebo or after administration of 9 days of dosing with either olanzapine or cimetidine. Subjects were divided into two groups. Group 1 received theophylline after olanzapine or placebo and group 2 received theophylline after cimetidine or placebo. Cimetidine (Tagamet) 400 mg orally 3 times/day was administered approximately every 8 hours for 9 days (27 total doses). Placebo was administered in the same manner as cimetidine or olanzapine, corresponding to study group. Aminophylline was admininstered as a single intravenous dose of 350 mg over 30 minutes on the last day of each treatment period, 1 hour after the morning dose of olanzapine, cimetidine or placebo. This dose is equivalent to 276.5 mg of anhydrous theophlline.
RESULTS: Administration of aminophylline with cimetidine resulted in a statistically significant increase in theophylline AUC and half-life."
|
| dc:creator | |
| dc:date |
"09/16/2010 13:53:17"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ cimetidine_increases_auc_theophylline, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1144 }