Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/51"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1424"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"13"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem
?:claim_assumed_valid_for_evidence_application_evidence_1424	?:quinidine_in_vitro_selective_inhibitor_of_enzyme_cyp2d6
?:content	"Enzyme system: human liver microsomes: NADPH added: yes inhibitor used: quinidine reaction: nefazodone --> OH-NEF ; nefazodone --> mCPP Quote: Incubations of human liver microsomes with NEF and the CYP3A4 inhibitor ketoconazole resulted in a concentration-dependent inhibition of the formation of mCPP and OH-NEF (Fig. 3). Incubations of human liver microsomes with NEF and the CYP2D6 inhibitor quinidine did not affect the production of OH-NEF and mCPP. Incubations of OH-NEF with the CYP3A4 inhibitor ketoconazole resulted in the inhibition of metabolite formation, and incubations with the CYP2D6 inhibitor quinidine did not, similar to what was found with NEF metabolism (data not presented)."
dc:creator	"boycer"
dc:date	"02/12/2010 13:56:37"
rdfs:seeAlso	?:11872324

The resource appears as object in one triple:

{ nefazodone_substrate_of_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1424 }

Context graph