Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/523"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"Route of administration: oral
study duration: a single dose of 400mg oral fluconazole followed by a single dose of 7.5mg midazolam 60 minutes later
population: 4 female and 5 male
ages: 19-25
AUC_i/AUC (0-inf):421/113 = 3.726
NOTE: The study shows a decrease in the ratio of 1-OH-MDZ to MDZ in the presence of fluconazole indicating that less of the parent is being converted to metabolite
description:
A double-dummy, randomized, cross-over study in three phases was performed in 9 healthy volunteers. The subjects were given orally fluconazole 400 mg and intravenously saline within 60 min; orally placebo and intravenously fluconazole 400 mg; and orally placebo and intravenously saline. An oral dose of 7.5 mg midazolam was ingested 60 min after oral intake of fluconazole/placebo, i.e. at the end of the corresponding infusion. Plasma concentrations of midazolam, alpha-hydroxymidazolam and fluconazole were determined and pharmacodynamic effects were measured up to 17 h. RESULTS: Both oral and intravenous fluconazole significantly increased the area under the midazolam plasma concentration-time curve (AUC0-3, AUC0-17) 2- to 3-fold, the elimination half-life of midazolam 2.5-fold and its peak concentration (Cmax) 2- to 2.5-fold compared with placebo. The AUC0-3 and the Cmax of midazolam were significantly higher after oral than after intravenous administration of fluconazole. Both oral and intravenous fluconazole increased the pharmacodynamic effects of midazolam but no differences were detected between the fluconazole phases."
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| dc:creator | |
| dc:date |
"12/10/2007 15:09:10"
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluconazole_increases_auc_midazolam, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1400 }