Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/540"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1272"
rdf:type	?:Evidence ?:Item
?:Evidence_enzyme_system	""
?:Evidence_type	?:Non_traceable_Drug_Label_Statement
?:content	"Paliperidone is not a substrate of CYP1A2, CYP2A6, CYP2C9, and CYP2C19, so that an interaction with inhibitors or inducers of these isozymes is unlikely. While in vitro studies indicate that CYP2D6 and CYP3A4 may be minimally involved in paliperidone metabolism, in vivo studies do not show decreased elimination by these isozymes and they contribute to only a small fraction of total body clearance. In vitro studies have shown that paliperidone is a P-gp substrate."
dc:creator	"boycer"
dc:date	"06102009"
rdfs:seeAlso	?:7b8e5b26-b9e4-4704-921b-3c3c0d159916

The resource appears as object in one triple:

{ paliperidone_inhibits_cyp2c19, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1272 }

Context graph