Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/574"

Predicate	Value (sorted: default)
rdfs:label	"evidence_1640"
rdf:type	?:Evidence ?:Item
?:Evidence_assump_list_id	"111"
?:Evidence_enzyme_system	""
?:Evidence_type	?:EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem
?:claim_assumed_valid_for_evidence_application_evidence_1640	?:quinidine_in_vitro_selective_inhibitor_of_enzyme_cyp2d6
?:content	"Enzyme system: human liver microsomes NADPH added: yes (a dehydrogenase generating system) reaction: R- and S-desmethylcitalopram (aka demethylcitalopram) --> R- and S- didemethylcitalopram Quote: Quinidine (5micM) reduced formation of DDCT from R- or S-DCT to only 70 to 80% of control (Fig. 7), whereas the same concentration of quinidine reduced formation of R- and S-DCT to less than 10% of control values in heterologously expressed CYP2D6."
dc:creator	"boycer"
dc:date	"06/12/2009 19:30:06"
rdfs:seeAlso	?:11454728

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ R-demethylcitalopram_substrate_of_cyp2d6, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1640 }

Context graph