Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/603"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1609"
|
| rdf:type | |
| ?:Evidence_assump_list_id |
"115"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1609 | |
| ?:content |
"Enzyme system: human liver microsomes
NADPH added: yes
inhibitor used: furafylline
reaction: haloperidol --> 4-(4-chlorophenyl)-4-hydroxypiperidine
Quote: Ketoconazole was a potent inhibitor of CPHP (4-(4-chlorophenyl)-4-hydroxypiperidine) formation with IC50 values of 0,10, 0,23 and 0,14 micM in microsomes HL-1, HL-6 and HL-9 respectively, wheras sulphaphenazole, furafylline and quinidine showed little inhibition (IC50 > 100micM)"
|
| dc:creator | |
| dc:date | |
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ cyp1a2_controls_formation_of_4-(4-chlorophenyl)-4-hydroxypiperidine, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1609 }