Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/606"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_assump_list_id |
"116"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1663 | |
| ?:content |
"Enzyme system: human liver microsomes:
NADPH added: yes
inhibitor used: ketoconazole
reaction: venlafaxine --> N-desmethylvenlafaxine
NOTE: the concentration of venlafaxine used in this experiment is very high relative to that expected in clinical use of the drug
Quote:
"Formation of NDV had a mean Vmax of 2.14 nmol min mg protein, and a mean Km of 2504 M (Table 2). Incubations of 750micM VF with SFZ and QUI led to 18% and 23% reduction in NDV production respectively, while increasing concentrations of ANA led to an 11% increase in NDV formation over baseline. KET [ketoconazole] had a more profound effect on NDV formation, leading to a 65% mean reduction in production of this metabolite (Figure 5).""
|
| dc:creator | |
| dc:date |
"06/20/2009 14:29:30"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ cyp3a4_controls_formation_of_N-desmethylvenlafaxine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1663 }