Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/610"
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?:Evidence_enzyme_system |
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"Enzyme system: recombinant human enzymes in human lymphoblastoid for CYP1A2 and CYP2D6; recombinant human enzymes in baculovirus-infected insect cells for CYP2C8, CYP2C9, and CYP2C19
NADPH added:yes
inhibitor used: no
When NEF or OH-NEF was incubated with microsomes from cells transfected with human cDNA for one of CYP1A1, CYP1A2, CYP2A6, CYP2D6, CYP3A4, CYP2C8, CYP2C9 arg, CYP2C9 cys, or CYP2C19, metabolite formation was seen with the CYP3A4 incubations only (Table 4)."
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All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ nefazodone_substrate_of_cyp2c8, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1240 }
Context graph