Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/679"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdf:type | |
| rdfs:label |
"evidence_1934"
|
| ?:Evidence_type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_value | |
| dc:creator | |
| dc:date |
"08/10/2010 14:29:24"
|
| ?:content |
"route of administration: oral
study duration: six days
population: 18 healthy subjects (9 male, 9 female) All Japanese
tested for known CYP450 polymorphisms?
CYP2C19 -- 6 homozygous EMs, 6 heterozygous EMs, and 6 poor metabolizers
ages: 21-34
description:
NOTE: AUC_I/AUC in the DIKB knowledge-base is from the 6 participants classified as homozygous EMs and the value is for the R-enantiomer. The AUC increase for the S-enantiomer was greater; please see the full text.
Eighteen healthy subjects, of whom six each were homozygous extensive metabolizers (homEMs), heterozygous extensive metabolizers (hetEMs), or poor metabolizers (PMs) for CYP2C19, participated in the study. Each subject received either placebo or fluvoxamine, 25 mg twice daily for 6 days, then a single oral dose of 60 mg of racemic lansoprazole. The plasma concentrations of lansoprazole enantiomers and lansoprazole sulphone were subsequently measured for 24 h post lansoprazole administration using liquid chromatography.
In the homEMs and hetEMs, fluvoxamine significantly increased the AUC(0, inf) and C max and prolonged the elimination half-life of both (R)- and (S)-lansoprazole, whereas in the PMs, the only statistically significant effect of fluvoxamine was on
the AUC(0, inf) for (R)-lansoprazole. The mean fluvoxamine-mediated percent increase in the AUC(0, inf) of (R)-lansoprazole in the homEMs compared with the PMs was significant ( P = 0.0117); however, C max did not differ among the three CYP2C19 genotypes. On the other hand, fluvoxamine induced a significant percent increase in both the AUC(0, inf) and C max for (S)-lansoprazole in the homEMs compared with the hetEMs ( P = 0.0007 and P = 0.0125, respectively) as well as compared with the PMs ( P < 0.0001 for each parameter)."
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ fluvoxamine_increases_auc_lansoprazole, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1934 }