Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/692"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_assump_list_id |
"135"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1324 | |
| ?:content |
"Enzyme system: human liver microsomes:
NADPH added: yes
inhibitor used: sulfinpyrazone
reaction: venlafaxine --> O-desmethylvenlafaxine
Quote:
Incubations of 50micM VF with varying concentra-
tions of SFZ and ANA, inhibitors of CYP2C9 and CYP1A2, respectively, revealed no consistent inhibitory effect on ODV formation...biotransformation of a substrate. In the present study, ODV was produced by cDNA-expressed CYP2C9, CY2C19, and CYP2D6, although we were unable to identify the contribution of CYP2C9 or CYP2C19 in liver microsomes using either chemical inhibition by SFZ or anti-2C antibodies in human microsomes."
|
| dc:creator | |
| dc:date |
"06/16/2009 14:21:24"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ cyp2c9_controls_formation_of_O-desmethylvenlafaxine, <http://purl.org/swan/1.2/swan-commons#citesAsRefutingEvidence>, evidence_1324 }