Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/693"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"route of administration: oral
study duration: 4 days
population: 12 healthy volunteers (all male); all nonsmokers
tested for known CYP450 polymorphisms? No
ages: 22-27
description:
SUBJECTS: Twelve healthy, nonsmoking male volunteers aged 22 to 27 years (weight range, 67-95 kg; body mass index range, 21-26 kg/m2) participated in this study after having given written informed consent. The subjects were ascertained to be in good health by medical history, a full clinical examination, and standard hematologic and blood chemical laboratory tests before enrollment.
METHODS: This study was an open crossover study with 3 phases. Between phases 1 and 2, there was a 1-week-long washout period, and between phases 2 and 3, there was a washout period of 2 weeks. The first phase was a control period, in which all volunteers received a single oral dose of bupropion (Zyban sustained release, 150 mg; GlaxoSmithKline, Uxbridge, United Kingdom). In the second and third phases the volunteers received a 4-day-long oral antiplatelet agent pretreatment in randomized balanced order with either clopidogrel (Plavix, 75 mg once daily; Sanofi Synthelabo, Guildford, United Kingdom) or ticlopidine
(Ticlid, 250 mg twice daily; Sanofi Synthelabo). On day 4, 1 hour after the last dose of the antiplatelet agent, a single 150-mg dose of bupropion was administered. Venous blood samples (10 mL each) for determination of bupropion and hydroxybupropion concentrations were taken just before and at 1, 2, 3, 4, 5, 6, 8, 12, 24, 48, and 72 hours after administration of bupropion. In all phases the volunteers fasted for 8 hours before
and 4 hours after administration of bupropion. Identical meals were provided on the 3 study days. Volunteers were also required to refrain from strenuous physical exercise, alcohol- or caffeine-containing drinks, smoking, grapefruit juice, and other medications for 2 days before and after study drug administration.
RESULTS: Both of the thienopyridine
derivatives had a significant effect on the AUC of
bupropion: in the clopidogrel phase, the bupropion
AUC increased by 60% (P = .02; 95% CI, 21% to
98%)."
|
| dc:creator | |
| dc:date |
"09/15/2010 14:16:12"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ clopidogrel_increases_auc_bupropion, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1051 }