Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/720"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label |
"evidence_1046"
|
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"NOTE: The object dose given and AUC are for EMs.
route of administration: not mentioned
study duration: not mentioned
population: 20 subjects
tested for known CYP450 polymorphisms?
YES - CYP2D6 -- 14 EMs, 6 PMs
ages:
Quote:
A pharmacokinetic study with ketoconazole 100 mg b.i.d. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6 resulted in higher plasma concentrations of both venlafaxine and O-desvenlafaxine (ODV) in most subjects following administration of ketoconazole. Venlafaxine Cmax increased by 26% in EM subjects and 48% in PM subjects. Cmax values for ODV increased by 14% and 29% in EM and PM subjects, respectively."
|
| dc:creator | |
| dc:date |
"02/16/2012 21:49:26"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ ketoconazole_increases_auc_venlafaxine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1046 }