Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/886"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose |
"0.125"
|
| ?:Evidence_type | |
| ?:Evidence_value | |
| ?:content |
"NOTE: The AUC_i/AUC value given is the AUC_0-inf taken from Table 1.
route of administration: oral
study duration: 6 days
population: 12 healthy Japanese volunteers (9 male, 3 female)
tested for known CYP450 polymorphisms?
Yes -- CYP2D6 genotypes - 4 with no mutated allele, 6 with one mutated allele, 2 with 2 mutated alleles
ages: 20-35
description:
SUBJECTS: Twelve healthy Japanese volunteers (nine males, three females) were enrolled in this study. Their mean +/- SD of age (range) was 24.8 +/- 2.5 (20–35) years and mean body weight was 58.3 +/- 8.5 (46–75) kg. The subjects had the following CYP2D6 genotypes: wt/wt (4 subjects), *10/wt (6), *10/*10 (1) and *5/*10 (1), respectively. No subjects regarded as poor metabolizers were included. These patients were divided into three groups according to the number of mutated alleles: no mutated allele in 4, one mutated allele in 6 and two mutated alleles in 2 subjects.
METHODS: A randomized crossover study design was conducted at intervals of 4 weeks. One capsule containing either 125 mg of terbinafine or a matched placebo with 240 ml of tap water was given once daily at 0800 hours for 6 days. Compliance of the test drug was confirmed by pill-count.
RESULTS: The AUC (0–48) of paroxetine during trebinafine treatment was higher than placebo by 2.53-fold (1.85, 4.58-fold). The total AUC of paroxetine during trebinafine treatment was higher than placebo by 2.88-fold (1.99, 5.41-fold)."
|
| dc:creator | |
| dc:date |
"09/15/2010 15:26:19"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ terbinafine_increases_auc_paroxetine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1720 }