Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/899"
| Predicate | Value (sorted: none) |
|---|---|
| rdf:type | |
| rdf:type | |
| rdfs:label |
"evidence_1938"
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| ?:Evidence_type | |
| ?:Evidence_enzyme_system | |
| ?:Evidence_numb_subjects | |
| ?:Evidence_object_dose | |
| ?:Evidence_precip_dose | |
| ?:Evidence_value | |
| dc:creator | |
| dc:date |
"05/05/2009 16:37:01"
|
| ?:content |
"Route of administration: oral
study duration: PK values of a single dose of desipramine was compared with the same values after eight days of treatment with desipramine + sertraline
population: 6 healthy males, all participants were extensive metabolizers of dextromethorphan (o-demethylation) (c.f. page 154, paragraph 3).
ages: mean(std dev):42 (9)
AUC_i/AUC (24 hour): 796/516 = 1.54
Description:
Participants received a 50 mg single dose of either desipramine or imipramine under three conditions: alone, after a single 150 mg dose of sertraline, and after the eighth daily 150 mg dose of sertraline. Plasma samples were analyzed for desipramine or imipramine concentration by HPLC with electrochemical detection, and pharmacokinetics were determined with use of noncompartmental analysis of individual data. RESULTS: Multiple-dose, but not single-dose, treatment with sertraline significantly reduced apparent plasma clearance (CL/F) and prolonged the half-life of desipramine relative to baseline. These changes resulted in higher plasma desipramine concentrations, as indicated by a significant increase in maximum plasma concentration (Cmax) and area under the plasma concentration-time curve extrapolated to infinity [AUC(0-infinity)] (22% and 54%, respectively). Both single- and multiple-dose treatment with sertraline significantly reduced the CL/F of imipramine. This effect was stronger after multiple predoses of sertraline, when imipramine Cmax and AUC(0-infinity) were increased by 39% and 68%, respectively. These treatment effects were consistent between individuals."
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| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ sertraline_increases_auc_desipramine, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1938 }