Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/912"
| Predicate | Value (sorted: default) |
|---|---|
| rdfs:label | |
| rdf:type | |
| ?:Evidence_assump_list_id |
"164"
|
| ?:Evidence_enzyme_system | |
| ?:Evidence_type | |
| ?:claim_assumed_valid_for_evidence_application_evidence_1375 | |
| ?:content |
"Enzyme system: human liver microsomes
NADPH added: yes
reaction: paclitaxel --> 6alpha-OH-paclitaxel
"No IC50 values could be determined for rosuvastatin and pravastatin with concentrations up to 100micM"
Concentration of pravastatin in vivo based on the largest C_max in label in table 1 of http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=1652:
3650ng/1ml x 1g/1e9ng x 1e3ml/1L = .004g/L
.004g/L x 1M/853.9g = 4.68micM/L"
|
| dc:creator | |
| dc:date |
"11/13/2007 13:39:32"
|
| rdfs:seeAlso |
All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl
The resource appears as object in one triple:
{ pravastatin_does_not_inhibit_cyp2c8, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1375 }