Local view for "https://dbmi-icode-01.dbmi.pitt.edu/dikb/resource/Evidence/93"

PredicateValue (sorted: default)
rdfs:label
rdf:type
?:Evidence_enzyme_system
?:Evidence_numb_subjects
?:Evidence_object_dose
?:Evidence_precip_dose
?:Evidence_type
?:Evidence_value
?:content
"Route of administration: oral study duration: four days pre-treatment with ketoconazole population: male: 2 female: 7 ages: 19-26 NOTE: AUC data taken from table 1 Interaction between ketoconazole, itraconazole, and midazolam was investigated in a double-blind, randomized crossover study of three phases at intervals of 4 weeks. Nine volunteers were given either 400 mg ketoconazole, 200 mg itraconazole, or matched placebo orally once daily for 4 days. On day 4, the subjects ingested 7.5 mg midazolam. Plasma samples were collected and psychomotor performance was measured. Both ketoconazole and itraconazole increased the area under the midazolam concentration-time curve from 10 to 15 times (p < 0.001) and mean peak concentrations three to four times (p < 0.001) compared with the placebo phase."
dc:creator
dc:date
"06/05/2007 07:52:40"
rdfs:seeAlso

All properties reside in the graph file:///home/swish/src/ClioPatria/guidelines/dikb.ttl

The resource appears as object in one triple:

{ ketoconazole_increases_auc_midazolam, <http://purl.org/swan/1.2/swan-commons#citesAsSupportingEvidence>, evidence_1226 }

Context graph