Triples with object Enzyme system: human liver microsomes: NADPH added: yes substrate used: midazolam reaction: midazolam 1'hydroxylation IC50 > 200micM (see Table 3) Quote: Pantoprazole showed a stronger inhibitory effect (Ki 22mM) on midazolam 1'-hydroxylation than omeprazole (Ki 42micM), esomeprazole (Ki 47micM), and rabeprazole (Ki 51micM). The IC50 of lansoprazole was over 200 M.